Genes, Circuits, & Behavior

We aim to understand the genetic and neural basis of brain functions in Drosophila. Our missions are: (i) to construct a wiring diagram of the entire fly brain; and (ii) to understand the design of individual circuits for both innate and learned behaviors.
Wiring diagram. We have generated a standard Drosophila brain for archiving and analysis of individual neurons. We are currently trying to construct (i) a mesoscopic map showing connections between different neuropilar regions; and (ii) a map of synaptic connectivity amongst olfactory neurons.
Brain functions. Our focus is on understanding circuits and genes involved in olfactory, auditory, gustatory, sleep, courtship, fighting, aging, fear, and learned behaviors.

Highlight

  • Lin CY, Chuang CC, Hua TE, Chen CC, Dickson BJ, Greenspan RJ, Chiang AS* (2013) A comprehensive wiring diagram of the protocerebral bridge for visual information processing in the Drosophila brain. Cell Reports 3, 1739-1753.
  • Lin HH, Chu LA, Fu TF, Dickson BJ, Chiang AS* (2013) Parallel neural pathways mediate CO2 avoidance responses in Drosophila. Science 340, 1338-1341.
  • Pai TP, Chen CC, Lin HH, Chin AL, Lai JSY, Lee PT, Tully T, Chiang AS* (2013) Drosophila ORB protein in two mushroom body-output neurons is necessary for long-term memory formation.Proc Natl Acad Sci USA 110, 7898-7903.
  • Chen CC, Wu JK, Lin HW, Pai TP, Fu TF, Wu CL, Tully T, Chiang AS* (2012) Visualizing long-term memory formation in two neurons of the Drosophila brain. Science 335, 678–685. (IF: 31) PDF (Faculty 1000 recommended; 101年大學指考試題39-41)
  • Lai JSY, Lo SJ, Dickson BJ and Chiang AS* (2012) Auditory circuit in the Drosophila brain. Proc Natl Acad Sci USA 109, 2607-2612. (IF: 10) PDF
  • Lee PT, Lin HW, Chang YH, Fu TF, Dubnau J, Hirsh J, Lee T and Chiang AS* (2011) A serotoni-nmushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila. Proc Natl Acad Sci USA 108, 13794–13799. (IF: 10) PDF
  • Wu CL, Shih MF Lai SY, Yang HT, Turner GC, Chen L, Chiang AS* (2011) Heterotypic gap junctions between two neurons in the Drosophila brain are critical for memory. Curr Biol 21, 848-854.(IF: 10) PDF
  • Chang YC, Hung WT, Chang YC, Chang HC, Wu CL, Chiang AS, Jackson GR, Sang TK*. (2011) Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD Model. PLoS Genetics 7, e1001288. (IF: 11) PDF

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