Connectomics; Behavioral Neurogenetics; Bioimaging

We aim to understand how genes and circuits orchestrate complex behavior in Drosophila. Three main approaches are taken: (i) to construct a brain-wide wiring diagram at single-cell resolution; (ii) to manipulate specific nodes in the circuits for understanding how brains encode and decode information; and (iii) to develop innovative technologies for functional connectomic research.

Recent Publications (2010-2019)

  • Feng KL and Chiang AS* (2019) Forgetting memories through distinct actin remodeling mechanisms. Proc Natl Acad Sci USA (in press) https://www.pnas.org/content/early/2019/09/16/1914578116
  • Chu LA#, Lu CH#, Yang SM, Liu YT, Feng KL, Tsai YCh, Chang WK, Wang WC, Chang SW, Chen P, Lee TK, Hwu YK, Chiang AS*, Chen BC* (2019) Rapid single-wavelength lightsheet localization microscopy for clarified tissue. Nature Communications (in press). (IF:12.353) https://doi.org/10.1038/s41467-019-12715-3
  • Sung YC, Jin PR, Chu LA, Hsu FF, Wang MR, Chang CC, Chiou SJ, Qiu JT, Gao DY, Lin CC, Chen YS, Hsu YC, Wang J, Wang FN, Yu PL, Chiang AS, Wu Anthony YT, Ko John JS, Lai Charles PK, Lu TT*, Chen Y* (2019) Nanotechnology-enabled delivery of nitric oxide promotes tumor vessel normalization and potentiates anti-cancer therapies. Nature Nanotecnology (in press). (IF:33.407)
  • Zhang Y, Tsang TK, Bushong EA, Chu LA, Chiang AS, Ellisman MH, Reingruber J, Su CY* (2019) Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons. Nature Communications 10: 1560. (IF:12.353) Link
  • Hwu Y*, Margaritondo G* and Chiang AS*. (2017). Q&A: Why use synchrotron x-ray tomography for multi-scale connectome mapping? BMC Biology 15: 122, doi: 10.1186/s12915-017-0461-8. (IF: 6.723)
  • Lo CC*, Chiang AS*. (2016). Toward whole-body connectomics. J Neurosci 36: 11375-11383. (IF: 6.074) (This review article is based on a Presidential Lecture at the Neuroscience 2016 Annual Meeting) Link
  • Shih HW, Wu CL, Chang SW, Liu TH, Jason Lai SY, Fu TF, Fu CC, Chiang AS*. (2015) Parallel Circuits Control Temperature Preference in Drosophila during Aging. Nature Communication 6:7775. (IF: 11.880) PDF
  • Shih CT*, Sporns O, Yuan SL, Su TS, Lin YJ, Chuang CC, Wang TY, Lo CC, Greenspan RJ, Chiang AS*. (2015, Apr). Connectomics-Based Analysis of Information Flow in the Drosophila Brain. Curr Biol 25: 1249-1258. (IF: 9.193) PDF
  • Schoofs A, Hückesfeld S, Schlegel P, Miroschnikow A, Bader R, Zeymer M, Spieß R, Chiang AS, Pankratz MJ*. (2014). Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain. PLoS Biol 12: e1001893. (IF: 11.771, 5-Year IF: 12.807) doi: 10.1371/journal.pbio.1001893
  • Chin AL, Lin CY, Fu TF, Dickson BJ, Chiang AS* (2014) Diversity and Wiring Variability of Visual Local Neurons in the Drosophila Medulla M6 Stratum. J Comp Neurol 522, 3795-3816. (IF:3.50). (IF:3.508, 5-Year IF:3.841) PDF
  • Wu MC, Chu LA, Hsiao PY, Lin YY, Chi CC, Liu TH, Fu CC*, Chiang AS*. (2014). Optogenetic control of selective neural activity in multiple freely moving Drosophila adults. Proc Natl Acad Sci USA 111: 5367-5372. (IF: 9.809, 5-Year IF: 10.727) PDF
  • Lin HH, Chu LA, Fu TF, Dickson BJ, Chiang AS*. (2013). Parallel neural pathways mediate CO2 avoidance responses in Drosophila. Science 340: 1338-1341. (IF: 31.477, 5-Year IF: 34.463; this article has been reviewed in the “PERSPECTIVES” of the same Science issue, p1295-1297) PDF
  • Lin CY, Chuang CC, Hua TE, Chen CC, Dickson BJ, Greenspan RJ, Chiang AS*. (2013). A comprehensive wiring diagram of the protocerebral bridge for visual information processing in the Drosophila brain. Cell Rep 3: 1739-1753. (IF: 7.207, 5-Year IF:7.215) DOI:https://doi.org/10.1016/j.celrep.2013.04.022
  • Pai TP, Chen CC, Lin HH, Chin AL, Lai JSY, Lee PT, Tully T, Chiang AS*. (2013). Drosophila ORB protein in two mushroom body-output neurons is necessary for long-term memory formation. Proc Natl Acad Sci USA 110: 7898-7903. (IF: 9.809, 5-Year IF: 10.727) PDF
  • Wu TH, Lu YN, Chuang CL, Wu CL, Chiang AS, Krantz DE, Chang HY. (2013). Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau. Acta Neuropathol 125: 711-725. (IF: 9.777, 5-Year IF: 8.854) doi: 10.1007/s00401-013-1105-x
  • Dubnau J*, Chiang AS*. (2013). Systems memory consolidation in Drosophila. Curr Opin Neurobiol 23: 84-91. (IF: 6.765, 5-Year IF: 7.549) PDF
  • Zhou C, Huang H, Kim S, Lin HW, Meng X, Chiang AS, Wang JW, Jiao R, Rao Y. (2012). Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning. J Neurosci 32: 14281-14287. (IF: 6.747, 5-Year IF: 7.648) Link
  • Chen CC, Wu JK, Lin HW, Pai TP, Fu TF, Wu CL, Tully T, Chiang AS*. (2012). Visualizing long-term memory formation in two neurons of the Drosophila brain. Science 335: 678–685. [101年大學指考試題39-41] (IF: 31.477, 5-Year IF: 34.463; cited by 30 articles; this article has been reviewed in the “PERSPECTIVES” of the same Science issue, p664-665; this article has been introduced by the Science Editor in the “EDITOR’S CHOICE” of the Science Signaling 14, ec50) PDF
  • Lai JSY, Lo SJ, Dickson BJ and Chiang AS*. (2012). Auditory circuit in the Drosophila brain. Proc Natl Acad Sci USA 109: 2607-2612. (IF: 9.809, 5-Year IF: 10.727) PDF
  • Chiang AS*. (2011). Q&A: Ann-Shyn Chiang. Curr Biol 21: R938-R939. (IF: 9.916, 5-Year IF: 10.227) PDF
  • Lee PT, Lin HW, Chang YH, Fu TF, Dubnau J, Hirsh J, Lee T and Chiang AS*. (2011). Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila. Proc Natl Acad Sci USA 108: 13794–13799. (IF: 9.809, 5-Year IF: 10.727) PDF
  • Wu CL, Shih MF Lai SY, Yang HT, Turner GC, Chen L, Chiang AS*. (2011). Heterotypic gap junctions between two neurons in the Drosophila brain are critical for memory. Curr Biol 21: 848-854. (IF: 9.916, 5-Year IF: 10.227; this article has been reviewed in the “Dispatch” of the Current Biology21, R394-R395) PDF
  • Chiang AS*, Lin CY, Chuang CC, Chang HM, Hsieh CH, Yeh CW, Shih CT, Wu JJ, Wang GT, Chen YC, Wu CC, Chen GY, Ching YT, Lee PC, Lin CY, Lin HH, Wu CC, Hsu HW, Huang YA, Chen JY, Chiang HJ, Lu CF, Ni RF, Yeh CY, Hwang JK. (2011). Three-dimensional reconstruction of brainwide wiring networks in Drosophila at single cell resolution. Curr Biol 21: 1-11. (Article, cover story) (IF: 9.916, 5-Year IF: 10.227;this article has been reviewed in the “Dispatch” of the Current Biology21, R19-R20)「紐約時報」專欄報導 PDF
  • Chang YC, Hung WT, Chang YC, Chang HC, Wu CL, Chiang AS, Jackson GR, Sang TK. (2011). Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD Model. PLoS Genet 7: e1001288. (IF: 8.167, 5-Year IF: 8.901) Link
  • Tamura T, Horiuchi D, Chen YC, Sone M, Miyashita T, Saitoe M, Yoshimura N, Chiang AS and Okazawa H. (2010). Drosophila PQBP1 regulates expression of NMDA receptor subunit NR1 and stores a very short-term memory in projection neurons. J Neurosci 30: 14091–14101. (IF: 6.747, 5-Year IF: 7.648) Link

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