Ann-Shyn Chiang Laboratory

Ann-Shyn Chiang Ph. D. 江安世 教授

簡介

江安世教授現職為國立清華大學的特聘講座教授，並擔任腦科學研究中心主任。其最高學歷為1990年於羅格斯大學 (Rutgers University) 取得的昆蟲學博士學位，畢業後於同一單位接受博士後研究訓練，1992年返臺，受聘於清華大學生命科學系擔任副教授，並於1997年升任教授職位。江教授在2001年於美國冷泉港實驗室休假進修期間開啟了以果蠅 (Drosophila) 作為學習記憶生物模型之研究歷程，後於2011年受邀成為加州大學聖地牙哥分校卡夫里腦科學研究所的國際研究學者。在他的研究生涯中，對於大腦圖譜解密以及記憶形成機制的研究有非常大的貢獻，也因此獲選為「中央研究院院士」(2014年) 以及「發展中世界科學院院士」(2016年)。
江教授是國際知名的神經科學權威，是我國第一位研究成果獲刊於《細胞》雜誌之學者，此篇論文發表了解析度到達單細胞層次之果蠅全腦網絡立體圖譜，廣受國內外媒體報導，紐約時報更盛讚此研究為人類全腦圖譜解碼之第一步。藉由此圖譜，江教授與跨領域研究團隊得以發現長期記憶的形成所需的新生蛋白質，僅發生於來自於腦中少數幾顆神經細胞內，並再次成為國內首位以長篇論文形式發表在《科學》雜誌之科學家。 江教授至今獲得的獎項肯定甚多，摘選如下：科技部（前國科會）傑出研究獎 (2004、2009、2012)，傑出人才基金會傑出人才講座 (2007)，教育部學術獎 (2007)，行政院傑出科技貢獻獎 (2007)，發展中世界科學院生物獎 (2012)，教育部國家講座(生物及醫農類科；2015、2020) 並晉身為終身榮譽國家講座主持人。 More About

代表著作(*: 通訊作者)

  1. Lin HW#, Chen CC#, de Belle JS, Tully T*, Chiang AS* (2021) CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 118, ppe2100624118. (IF: 11.205) [DOI]
  2. Chu LA#, Lu CH#, Yang SM, Liu YT, Feng KL, Tsai YCh, Chang WK, Wang WC, Chang SW, Chen P, Lee TK, Hwu YK, Chiang AS*, Chen BC* (2019) Rapid single-wavelength lightsheet localization microscopy for clarified tissue. Nature Communications 10, 4762. (IF: 14.919)[DOI]
  3. Feng KL and Chiang AS* (2019) Forgetting memories through distinct actin remodeling mechanisms. Proc. Natl. Acad. Sci. U.S.A. 116, 20807–20808. (IF: 11.205) [Link]
  4. Sung YC, Jin PR, Chu LA, Hsu FF, Wang MR, Chang CC, Chiou SJ, Qiu JT, Gao DY, Lin CC, Chen YS, Hsu YC, Wang J, Wang FN, Yu PL, Chiang AS, Wu Anthony YT, Ko John JS, Lai Charles PK, Lu TT*, Chen Y* (2019) Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies. Nature Nanotechnology 14, 1160-1169. (IF: 39.213)
  5. Zhang Y, Tsang TK, Bushong EA, Chu LA, Chiang AS, Ellisman MH, Reingruber J, Su CY* (2019) Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons. Nature Communications 10, 1560. (IF: 14.919)
  6. Shih HW, Wu CL, Chang SW, Liu TH, Lai JSY, Fu TF, Fu CC, Chiang AS* (2015) Parallel circuits control temperature preference in Drosophila during aging. Nature Communications 6, 7775. (IF: 14.919)
  7. Shih CT*, Sporns O, Yuan SL, Su TS, Lin YJ, Chuang CC, Wang TY, Lo CC, Greenspan RJ, Chiang AS* (2015) Connectomics-based analysis of information flow in the Drosophila brain. Current Biology 25, 1249-1258. (IF: 10.834)
  8. Wu MC, Chu LA, Hsiao PY, Lin YY, Chi CC, Liu TH, Fu CC*, Chiang AS* (2014) Optogenetic control of selective neural activity inmultiple freely moving Drosophila adults. Proc. Natl. Acad. Sci. U.S.A. 111, 5367-5372. (IF: 11.205)
  9. Wu CL, Shih MF M, Lee PT, Chiang AS* (2013) An octopamine–mushroom body circuit modulates the formation of anesthesia-resistant memory in Drosophila. Current Biology 23, 1-9. (IF: 10.834)
  10. Lin HH, Chu LA, Fu TF, Dickson BJ, Chiang AS* (2013) Parallel neural pathways mediate CO2 avoidance responses in Drosophila. Science 340, 1338-1341. (IF: 47.728 ; this article has been reviewed in the “PERSPECTIVES” of the same Science issue, p1295-1297)
  11. Pai TP, Chen CC, Lin HH, Chin AL, Lai JSY, Lee PT, Tully T, Chiang AS* (2013) Drosophila ORB protein in two mushroom body-output neurons is necessary for long-term memory formation. Proc. Natl. Acad. Sci. U.S.A. 110, 7898-7903. (IF: 11.205)
  12. Lehnert BP, Baker AE, Gaudry Q, Chiang AS, Wilson RI* (2013) Distinct roles of TRP channels in auditory transduction and amplification in Drosophila. Neuron 77, 115-128. (IF: 15.982)
  13. Chen CC, Wu JK, Lin HW, Pai TP, Fu TF, Wu CL, Tully T, Chiang AS* (2012) Visualizing long-term memory formation in two neurons of the Drosophila brain. Science 335, 678–685. [101年大學指考試題39-41] (IF: 47.728; cited by 99 articles; this article has been reviewed in the “PERSPECTIVES” of the same Science issue, p664-665; this article has been introduced by the Science Editor in the “EDITOR’S CHOICE” of the Science Signaling 14, ec50)
  14. Lai JSY, Lo SJ, Dickson BJ and Chiang AS* (2012) Auditory circuit in the Drosophila brain. Proc. Natl. Acad. Sci. U.S.A. 109, 2607-2612. (IF: 11.205)
  15. Chiang AS* (2011) Q&A: Ann-Shyn Chiang. Current Biology 21, R938-R939. (IF: 10.834)
  16. Lee PT, Lin HW, Chang YH, Fu TF, Dubnau J, Hirsh J, Lee T and Chiang AS* (2011) Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 108, 13794–13799. (IF: 11.205)
  17. Wu CL, Shih MF Lai SY, Yang HT, Turner GC, Chen L, Chiang AS* (2011) Heterotypic gap junctions between two neurons in the Drosophila brain are critical for memory. Current Biology 21, 848-854. (IF: 10.834; this article has been reviewed in the “Dispatch” of the Current Biology 21, R394-R395)
  18. Chiang AS*, Lin CY, Chuang CC, Chang HM, Hsieh CH, Yeh CW, Shih CT, Wu JJ, Wang GT, Chen YC, Wu CC, Chen GY, Ching YT, Lee PC, Lin CY, Lin HH, Wu CC, Hsu HW, Huang YA, Chen JY, Chiang HJ, Lu CF, Ni RF, Yeh CY, Hwang JK (2011) Three-dimensional reconstruction of brainwide wiring networks in Drosophila at single cell resolution. Current Biology 21,1-11. (Article, cover story) (IF: 10.834; cited by 325 articles; this article has been reviewed in the “Dispatch” of the Current Biology 21, R19-R20)「紐約時報」專欄報導
  19. Wu CL, Xia S, Fu TF, Wang H, Chen YH, Leong D, Chiang AS*, Tully T* (2007) Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body. Nature Neuroscience 10, 1578-1586. (IF: 24.884)
  20. Lin HH, Lai JSY, Chin AL, Chen YC, Chiang AS* (2007) A map of olfactory representation in the Drosophila mushroom body. Cell 128, 1205-1218. (IF: 41.582)
  21. Zhu S, Lin S, Kao CF, Awasaki T, Chiang AS, Lee T* (2006) Gradients of the Drosophila chinmo BTB-zinc finger protein govern neuronal temporal identity. Cell 127, 409-422. (IF: 41.582)
  22. Xia S, Miyashita T, Fu TF, Lin WY, Wu CL, Pyzocha L, Lin IR, Saitoe M, Tully T, Chiang AS* (2005) NMDA receptors mediate olfactory learning and memory in Drosophila. Current Biology 15, 603-615. (IF: 10.834; this article has been reviewed in the “Dispatch” of the Current Biology 15, R414-R419)
  23. Agrawal N, Pallos J, Slepko N, Apostol BL, Bodai L, Chang LW, Chiang AS, Thompson LM, Marsh JL (2005) Identification of combinatorial drug regimens for treatment of Huntington’s disease using Drosophila. Proc. Natl. Acad. Sci. U.S.A. 102, 3777-3781. (IF: 11.205)
  24. Iijima K, Liu HP, Chiang AS, Konsolaki M, Zhong Y* (2004) Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 101, 6623-6628. (IF: 9.809)
  25. Tamura T, Chiang AS, Ito N, Liu HP, Horiuchi J, Tully T, Saitoe M* (2003) Aging specifically impairs amnesiac-dependent memory in Drosophila. Neuron 40, 1003-1011. (IF: 15.982)
  26. Chiang AS*, Lin WY, Liu HP, Pszczolkowski MA, Fu TF, Chiu SL, Holbrook GL (2002) Insect NMDA receptors mediate juvenile hormone biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 99, 37-42. (IF: 11.205)
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